Finally, cashew‐sensitized mice were treated with cashew patches (EPIT) for up to 16 weeks to measure the kinetic induction of specific antibodies and the level of protection afforded against anaphylaxis following oral challenge. Then, the ability of patches to deliver cashew allergens to skin dendritic cells was demonstrated. To that end, a mouse model of IgE‐mediated cashew anaphylaxis was first developed. In that context, the aim of the present work was to assess the capacity of EPIT to protect against anaphylaxis in a mouse model of cashew allergy. This route of administration is a key element of the safety profile of EPIT, making it a relevant approach for the treatment of life‐threatening allergies such as cashew. This system comprised an allergen‐adsorbed patch that promotes allergen delivery across the stratum corneum to epidermal Langerhans cells. Investigational epicutaneous immunotherapy (EPIT) includes applying an epicutaneous system on intact skin (Viaskin). The prevalence of cashew allergy has risen over the last two decades in industrial countries with the increasing consumption of this nut.īesides the prevalence, a high medical need for a treatment is warranted by the unique severity of anaphylactic reactions triggered by the consumption of cashew‐containing food in allergic individuals.Ĭonsequently, safe treatments minimizing contact between cashew allergens and anaphylaxis‐triggering effector cells, such as mast cells, should be given paramount considerations. Unfortunately, cashew is also classified as one of the most potent allergenic food, and no approved specific treatment is available to address this issue. It produces cashew seeds (nuts) that are regularly consumed by most of the world's population. Published by John Wiley & Sons Ltd.The cashew plant ( Anacardium occidentale) is a tropical evergreen tree belonging to the Anacardiaceae family, which includes mango and pistachio. Considering its positive predictive value, it might allow to make a considerable number of oral challenges superfluous.Īna o 3 allergen-specific IgE cashew children component-resolved diagnostics food allergy. Specific IgE to Ana o 3 is a valuable tool for the diagnosis of cashew allergy. Probability curves for Ana o 3-specific IgE have been calculated, and a 95% probability could be estimated at 2.0 kU/l. The ratio of Ana o 3-specific IgE to total IgE did not further improve the diagnostic procedure. In receiver operating curves, Ana o 3 discriminates between allergic and tolerant children better than cashew-specific IgE with an area under the curve of 0.94 vs 0.78. Forty-two were allergic to cashew, and 19 were tolerant. In a multicentre study, we analysed specific IgE to cashew extract and Ana o 3 as well as total IgE in children with suspected cashew allergy using the ImmunoCAP-FEIA and a standardized diagnostic procedure including oral challenges where indicated.Ī total of 61 patients were included in the study. Moreover, the value of additional determination of total IgE has been investigated. The aim of this study was to investigate the role of Ana o 3-specific serum IgE in the diagnosis of cashew allergy and to identify cut-off levels to replace oral food challenges. Component-resolved diagnostics using specific IgE to 2 S albumins has shown to be a valuable new option in diagnostic procedure.
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